Publications

Le 07 Déc 2020

Publications

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2007

Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.

Fine-tuning of NMDA glutamatergic receptor signalling strategically controls crucial brain functions. This process depends on several ligands and modulators, one (…)

Consulter

2007

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects.

Desmoteplase, a recombinant form of the plasminogen activator DSPAalpha1 from Desmodus rotundus, may offer improved clinical benefits for acute ischemic (…)

Consulter

2007

Ageing and amyloid-beta peptide deposition contribute to an impaired brain tissue plasminogen activator activity by different mechanisms.

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder in the ageing population. It is characterized by the (…)

Consulter

2007

Mouse model of in situ thromboembolic stroke and reperfusion.

Early reperfusion using tissue-type plasminogen activator is the only therapeutic agent to treat focal cerebral ischemia with proven efficacy in (…)

Consulter

2007

Neuroprotection and stroke: time for a compromise.

In April 2007, there existed a repertory of 286 trials concerned with acute ischemic stroke on the Stroke Trials Registry (…)

Consulter

2007

EPR and optical studies of erbium-doped beta-PbF2 single-crystals and nanocrystals in transparent glass-ceramics.

beta-PbF(2) single-crystals and nanocrystals in transparent glass-ceramics doped with ErF(3) have been synthesized and studied with two complementary techniques: electron (…)