Publications

Le 07 Déc 2020

Publications

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2026

Inhibition of tPA-NMDAR interaction prevents neurovascular and functional deficits induced by organophosphorus nerve agents.

Organophosphorus compounds (OP), including pesticides and nerve agents such as sarin, soman and Novichok, irreversibly inhibit cholinesterases (ChE), resulting in (…)

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2026

Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer’s disease biomarkers.

The locus coeruleus (LC), the first region to contain tau pathology in Alzheimer’s disease (AD), releases norepinephrine, which has a (…)

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2026

Endothelial tPA-dependent recruitment of microglia to vessels protects the blood-brain barrier after stroke.

Ischemic stroke is one of the leading causes of death and disability worldwide and thrombolysis, with tissue-type plasminogen activator (tPA) (…)

Consulter

2026

Endothelial NMDA receptor involvement in retinal neurovascular damage following prenatal alcohol exposure in mouse model.

Prenatal alcohol exposure (PAE) induces neurodevelopmental damage leading to fetal alcohol spectrum disorders (FASD) by altering both brain and ocular (…)

Consulter

2026

Timing-Dependent Cleavage of Interleukin-1 Receptor Antagonist by Alteplase Impairs Neuroprotection in Ischemic Stroke.

Inflammation contributes significantly to neuronal damage in ischemic stroke, with IL (interleukin)-1 being a key mediator. IL-1Ra (IL-1 receptor antagonist) (…)