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Le 07 Déc 2020

Publications

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2011

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator.

Owing to its ability to generate the clot-dissolving protease plasmin, tissue plasminogen activator (tPA) is the only approved drug for (…)

2011

Tissue plasminogen activator prevents white matter damage following stroke.

Tissue plasminogen activator (tPA) is the only available treatment for acute stroke. In addition to its vascular fibrinolytic action, tPA (…)

2011

Stroke and the immune system: from pathophysiology to new therapeutic strategies.

Stroke is the second most common cause of death worldwide and a major cause of acquired disability in adults. Despite (…)

2011

Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF.

Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes (…)

2010

Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke.

Despite its fibrinolytic effect, tissue-type plasminogen activator (tPA) displays deleterious effects in the brain, including proexcitotoxicity, that can reduce the (…)

2011

Interaction study between rtPA and bevacizumab.

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