Publications

Le 07 Déc 2020

Publications

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2012

GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.

Tissue plasminogen activator (tPA) is a serine protease with pleiotropic actions in the CNS, such as synaptic plasticity and neuronal (…)

Consulter

2012

Traumatic brain injury: tissue-type plasminogen activator–harmful or beneficial?

Consulter

2012

Experimental modeling of recombinant tissue plasminogen activator effects after ischemic stroke.

Recombinant tissue plasminogen activator (rt-PA) is currently the only approved drug for ischemic stroke treatment, with a dose of 0.9 (…)

Consulter

2012

Memantine improves safety of thrombolysis for stroke.

Despite side effects including N-methyl-d-aspartate-mediated neurotoxicity, recombinant tissue-type plasminogen activator (rtPA) remains the only approved acute treatment for ischemic stroke. (…)

Consulter

2012

Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.

Since endothelial cells can be targeted by large contrast-carrying particles, molecular imaging of cerebrovascular cell activation is highly promising to (…)

Consulter

2012

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.

Unlike other serine proteases that are zymogens, the single-chain form of tissue plasminogen activator (sc-tPA) exhibits an intrinsic activity similar (…)