Thrombotic stroke in the anesthetized monkey (Macaca mulatta): characterization by MRI–a pilot study.
Auteur : Gauberti M, Obiang P, Guedin P, Balossier A, Gakuba C, Diependaele AS, Chazalviel L, Vivien D, Young AR, Agin V, Orset C
Année : 2012
Journal : Cerebrovasc Dis 1421-9786
PubMed Id : 22343114
The lack of a relevant stroke model in large nonhuman primates hinders the development of innovative diagnostic/therapeutic approaches concerned with this cerebrovascular disease. Our objective was to develop a novel and clinically relevant model of embolic stroke in the anesthetized monkey that incorporates readily available clinical imaging techniques and that would allow the possibility of drug delivery including strategies of reperfusion.