Plasminogen in cerebrospinal fluid originates from circulating blood.

Le 02 Nov 2021

Auteur : Mezzapesa A, Orset C, Plawinski L, Doeuvre L, Martinez de Lizarrondo S, Chimienti G, Vivien D, Mansour A, Matà S, Pepe G, Anglés-Cano E

Année : 2014

Journal : J Neuroinflammation 1742-2094

PubMed Id : 25220760

Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory diseases; however, its origin remains controversial, as the blood-CSF barrier may restrict its diffusion from blood.