PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models.
Auteur : Lebas H, GuÃ©rit S, Picot A, Boulay AC, Fournier A, Vivien D, Cohen Salmon M, Docagne F, Bardou I
Année : 2022
Journal : Cell Mol Life Sci 1420-9071
PubMed Id : 35633384
In multiple sclerosis (MS), disturbance of the plasminogen activation system (PAS) and blood brain barrier (BBB) disruption are physiopathological processes that might lead to an abnormal fibrin(ogen) extravasation into the parenchyma. Fibrin(ogen) deposits, usually degraded by the PAS, promote an autoimmune response and subsequent demyelination. However, the PAS disruption is not well understood and not fully characterized in this disorder.