Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate.
Auteur : Chuquet J, Benchenane K, Liot G, FernÃ¡ndez-Monreal M, Toutain J, Blanchet S, Eveno E, Auffray C, Piétu G, Buisson A, Touzani O, MacKenzie ET, Vivien D
Année : 2002
Journal : J Cereb Blood Flow Metab 0271-678X
PubMed Id : 12368653
To correlate brain metabolic status with the molecular events during cerebral ischemia, a cDNA array was performed after positron emission tomography scanning in a model of focal cerebral ischemia in baboons. Cluster analysis for the expression of 74 genes allowed the identification of 4 groups of genes. In each of the distinct groups, the authors observed a marked inflection in the pattern of gene expression when the CMRo was reduced by 48% to 66%. These patterns of coordinated modifications in gene expression could define molecular checkpoints for the development of an ischemic infarct and a molecular definition of the penumbra.