Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
Auteur : Gauberti M, Martinez de Lizarrondo S, Orset C, Vivien D
Année : 2014
Journal : J Thromb Haemost 1538-7836
PubMed Id : 24354644
Secondary microthrombosis is a major pathophysiologic mechanism leading to brain damage following transient mechanical vascular occlusion (TMVO), the most widely used experimental stroke model. Whether secondary microthrombosis also occurs in non-TMVO stroke models represents an important issue for clinical translation of antimicrothrombosis therapeutic strategies.