Efficacy of N-acetylcysteine in enhancing paracetamol’s analgesic effect and inhibiting hepatotoxicity: a preclinical mouse model.

Paracetamol (PCM) is extensively administered in clinical settings to alleviate mild to moderate pain and/or decrease fever. However, noncompliance with prescribed dosages can lead to severe and irreversible liver damage from PCM overdose. Although N-acetylcysteine (NAC) serves as the standard antidote for PCM toxicity, no commercially available combination of PCM and NAC has been marketed to mitigate its toxic effects. This study aims to evaluate both the antinociceptive and hepatoprotective effects of the PCM and NAC combination in a murine model.