Bumetanide lowers acute hydrocephalus in a rat model of subarachnoid hemorrhage.

Le 01 Mar 2022

Auteur : Metayer T, Orset C, Ali C, Furon J, Szabla N, Emery E, Vivien D, Gaberel T

Année : 2022

Journal : Acta Neurochir (Wien) 0942-0940

PubMed Id : 35094147

Subarachnoid hemorrhage (SAH) can lead to acute hydrocephalus (AH). AH pathophysiology is classically attributed to an obstruction of the arachnoid granulations by blood. Recent findings in rodents suggest that after intraventricular hemorrhage, AH is related to cerebrospinal fluid (CSF) hypersecretion by the choroid plexus (CP), as it can be reduced by intracerebroventricular (ICV) injection of bumetanide.