Bumetanide lowers acute hydrocephalus in a rat model of subarachnoid hemorrhage.
Auteur : Metayer T, Orset C, Ali C, Furon J, Szabla N, Emery E, Vivien D, Gaberel T
Année : 2022
Journal : Acta Neurochir (Wien) 0942-0940
PubMed Id : 35094147
Subarachnoid hemorrhage (SAH) can lead to acute hydrocephalus (AH). AH pathophysiology is classically attributed to an obstruction of the arachnoid granulations by blood. Recent findings in rodents suggest that after intraventricular hemorrhage, AH is related to cerebrospinal fluid (CSF) hypersecretion by the choroid plexus (CP), as it can be reduced by intracerebroventricular (ICV) injection of bumetanide.