Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.
Auteur : Chételat G
Année : 2013
Journal : Nat Rev Neurol 1759-4766
PubMed Id : 23399647
The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.