Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.

Le 02 Nov 2021

Auteur : Chételat G

Année : 2013

Journal : Nat Rev Neurol 1759-4766

PubMed Id : 23399647

The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.