Brain neurovascular unit biomarkers: a hypothesis-driven paradigm to advance understanding of post-cardiac arrest cerebral injury.

To examine the pathophysiology of cerebral complications following cardiac arrest, to summarise the current state of neurological prognostication, and to explore, as a hypothesis-driven paradigm, how the biological signature of brain neurovascular unit injury, captured through a panel of emerging and innovative biomarkers, may serve as a predictive and/or diagnostic tool for cognitive impairment and overall neurological prognosis in the medium, and long term post-cardiac arrest.